Mingueza should keep starting until Araujo is fit as Frenkie doesn't offer much as CB.
Time for Koeman to shoehorn Griezmann, Messi and Coutinho because of status.
Cou was probably our best player before his injury, when he played behind Messi. But I doubt we'll see him there unless there's an injury.
Best option at the moment would be to rotate Griezmann, Messi and Coutinho in the two central positions, the three of them can't play together.