I'd go with a semi-rotated lineup.
Neto; Dest*, Mingueza, Lenglet, Firpo; Pjanić, Busi, Puig; Trincao, Braithwaite, Messi
*If he's fit, otherwise don't risk him
I'd rest Araujo, Griezmann, Pedri and Dembele here, they've accumulated a lot of minutes in last two weeks with all the extra times we've played. With Busi suspended for Bilbao he'll surely start and Messi will also retun. FDJ could come off the bench.
I've watched Rayo's game against Mallorca on Saturday and they were 3-0 down after 20 minutes. They want to play from the back and they've done some bad mistakes in the build up so I'd press them high. They probably won't play the same way against us though.